It is possible to use ASP.NET Full Trust

Websites on your VPS will by default be running in Full Trust mode, which means you can install and host any .NET application on your VPS.

This means that you are guaranteed to be able to host systems like Umbraco, DotNetNuke, nopCommerce and many others.

For mere information about IIS and Full Trust:

Configuring .NET Trust Levels in IIS 7

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